Aggressive Angiomyxoma of the Cervix: A Unique Entity
Article Sidebar
Main Article Content
Abstract
Introduction: Aggressive angiomyxoma is a mesenchymal tumour which presents rarely; usually in women in reproductive age group, as a mass in the pelvic tissue. Only exceptionally, has it been seen to originate from the uterus and cervix.
Methods: We present a case of a 23-year-old woman who complained about abdominal pain and excessive vaginal bleeding three days after a spontaneous abortion. Examination revealed a large polyp arising from the cervix. Histopathologic examination of the polypectomy specimen revealed an aggressive angiomyxoma of the cervix. Immunohistochemistry was performed and the tumour was immunopositive for vimentin, desmin and smooth muscle actin. Management options are discussed, in light of need of fertility conservation.
Result: Aggressive angiomyxoma can originate from the mesenchymal tissue of the cervix.
Conclusions: Treatment may be individualized with surgery and hormonal treatment. Long term follow up is recommended.
Downloads
Article Details
Copyright (c) 2014 Siwatch S, et al.
This work is licensed under a Creative Commons Attribution 4.0 International License.
Steeper TA, Rosai J (1983) Aggressive angiomyxoma of the female pelvis and perineum. Report of nine cases of a distinctive type of gynecologic soft-tissue neoplasm. Am J Surg Pathol 7: 463-475.
Chan YM, Hon E, Ngai SW, Ng TY, Wong LC (2000) Aggressive angiomyxoma in females: is radical resection the only option? Acta Obstet Gynecol Scand 79: 216-220.
Han-Geurts IJ, van Geel AN, van Doorn L, den Bakker M, Eggermont AM, et al. (2006) Aggressive angiomyxoma: multimodality treatments can avoid mutilating surgery. Eur J Surg Oncol 32: 1217-1221.
Behranwala KA, Thomas JM (2003) ‘Aggressive' angiomyxoma: a distinct clinical entity. Eur J Surg Oncol 29: 559-563.
Yaghoobian J, Zinn D, Ramanathan K, Pinck RL, Hilfer J (1987) Ultrasound and computed tomographic findings in aggressive angiomyxoma of the uterine cervix. JUM 6: 209-212.
Skálová A, Zámecník M, Michal M, Opatrny V (2000) Aggressive angiomyxoma presenting as polyp of uterine cavity. Pathol Res Pract 196: 719-725.
Bagga R, Keepanasseril A, Suri V, Nijhawan R (2007) Aggressive angiomyxoma of the vulva in pregnancy: a case report and review of management options. Med GenMed 9:16.
Zhang P, Song K, Li L, Geng F, Li J, et al. (2011) Aggressive angiomyxoma with massive ascites. Gynecol Oncol Case Rep 1: 12-13.
Laskin WB, Fetsch JF, Tavassoli FA (2001) Superficial cervicovaginal myofibroblastoma: fourteen cases of a distinctive mesenchymal tumor arising from the specialized subepithelial stroma of the lower female genital tract. Hum Pathol 32: 715-725.
Layfield LJ, Dodd LG (1997) Fine-needle aspiration cytology findings in a case of aggressive angiomyxoma: a case report and review of the literature. Diagn Cytopathol 16: 425-429.
Haldar K, Martinek IE, Kehoe S (2010) Aggressive angiomyxoma: a case series and literature review. Eur J Surg Oncol 36: 335-339.
Tsarpalis DC, Giannakopoulos CK, Lagadas AA, Toufexi EG (2007) Aggressive angiomyxoma: case report and review of the literature. Eur J Gynaecol Oncol 28: 480-482.
Lee CW, Yoon JH, Park DC, Lee SJ (2011) Aggressive angiomyxoma of the vulva treated by using a gonadotropin-releasing hormone agonist: a case report. Eur J Gynaecol Oncol 32: 686-688.
Poirier M, Fraser R, Meterissian S (2003) Case 1. Aggressive angiomyxoma of the pelvis: response to luteinizing hormone-releasing hormone agonist. J Clin Oncol 21: 3535-3536.
Rhomberg W, Jasarevic Z, Alton R, Kompatscher P, Beer G, et al. (2000) Aggressive angiomyxoma: irradiation for recurrent disease. Strahlenther Onkol 176: 324-326.
Coppola S, Desai A, Tzanis D, Honoré C, Bitsakou G, et al. (2013) Conservative en bloc surgery for aggressive angiomyxoma achieves good local control: analysis of 14 patients from a single institution. Int J Gynecol Cancer 23: 540-545.
Bai HM, Yang JX, Huang HF, Cao DY, Chen J, et al. (2013) Individualized managing strategies of aggressive angiomyxoma of female genital tract and pelvis. Eur J Surg Oncol 39: 1101-1108.