Bone and Joint Infection Caused by Clindamycin and Penicillin-G Resistant, Toxigenic

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Global Journal of Medical and Clinical Case Reports volume12-issue3 articles
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Submitted: February 24, 2025
Published: Mar 4, 2025
DOI: 10.17352/2455-5282.000202
Keywords:
Corynebacterium ulcerans, Bone and joint infection, Tox gene

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José Bras-Cachinho
Department of Bacteriology-Virology-Hospital Hygiene, Tours University Hospital, Tours, France
Coralie Lemaire*
Department of Bacteriology-Virology-Hospital Hygiene, Tours University Hospital, Tours, France
Laura Chaufour
Tours Study Group Member of CRIOGO (Reference Center for Osteoarticular Infections), Tours, Centre-Val de Loire, France
Nadège Lépine
University of Tours, INRAE, Infectiology and Public Health, BRMF, Tours, France
Louis Bernard
Tours study group member of CRIOGO (Reference Center for Osteoarticular Infections), Tours, Centre-Val de Loire, France / CHRU de Tours, Tours, France
Marie-Frédérique Lartigue*
Service de Bactériologie-Virologie-Hygiène Hospitalière, CHRU de Tours, Tours, France / Université de Tours, INRAE, Infectiologie et Santé Publique, BRMF, Tours, France/ /Université de Tours, INRAE, Infectiologie et Santé Publique, BRMF, Tours, France / Tours study group member of CRIOGO (Reference Center for Osteoarticular Infections), Tours, Centre-Val de Loire, France

Abstract

Abstract


Corynebacterium diphtheriae, C. ulcerans, and C. tuberculosis are the three species belonging to the diphtheriae complex. C. While C. diphtheriae infections are becoming rare in developed countries, thanks to vaccination, C. ulcerans and C. pseudotuberculosis infections still are rare but increase and are often caused by contact with domestic animals. It should be noted, however, that vaccination protects against diphtheria toxin-producing strains. Here we report an uncommon case of bone and joint infection caused by toxigenic Corynebacterium ulcerans resistant to both clindamycin and penicillin G, in a vaccinated patient. This patient owned a dog whose samples showed carriage of toxigenic C. ulcerans.

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Article Details

Bras-Cachinho, J., Coralie Lemaire*, Chaufour, L., Lépine, N., Bernard, L., & Lartigue*, M.-F. (2025). Bone and Joint Infection Caused by Clindamycin and Penicillin-G Resistant, Toxigenic. Global Journal of Medical and Clinical Case Reports, 12(3), 070–072. https://doi.org/10.17352/2455-5282.000202
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Copyright (c) 2025 Bras-Cachinho J, et al.

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Hacker E, Antunes CA, Mattos-Guaraldi AL, Burkovski A, Tauch A. Corynebacterium ulcerans, an emerging human pathogen. Future Microbiol. 2016;11:1191–1208. Available from: https://doi.org/10.2217/fmb-2016-0085

Wagner KS, White JM, Crowcroft NS, De Martin S, Mann G, Efstratiou A. Diphtheria in the United Kingdom, 1986-2008: the increasing role of Corynebacterium ulcerans. Epidemiol Infect. 2010;138:1519–1530. Available from: https://doi.org/10.1017/s0950268810001895

CNR activity reports on Corynebacteria of the diphtheriae complex. Institut Pasteur. 2023. Available from: https://www.pasteur.fr/fr/sante-publique/CNR/les-cnr/corynebacteries-du-complexe-diphtheriae/rapports-d-activite

Museux K, Arcari G, Rodrigo G, Hennart M, Badell E, Toubiana J, et al. Corynebacteria of the diphtheriae species complex in companion animals: clinical and microbiological characterization of 64 cases from France. Microbiol Spectr. 2023;11(3):e0000623. Available from: https://doi.org/10.1128/spectrum.00006-23

Bonmarin I, Guiso N, Le Flèche-Matéos A, Patey O, Patrick AD, Levy-Bruhl D. Diphtheria: a zoonotic disease in France? Vaccine. 2009;27:4196–4200. Available from: https://doi.org/10.1016/j.vaccine.2009.04.048

Meinel DM, Margos G, Konrad R, Krebs S, Blum H, Sing A. Next generation sequencing analysis of nine Corynebacterium ulcerans isolates reveals zoonotic transmission and a novel putative diphtheria toxin-encoding pathogenicity island. Genome Med. 2014;6:113. Available from: https://doi.org/10.1186/s13073-014-0113-3

Katsukawa C, Komiya T, Yamagishi H, Ishii A, Nishino S, Nagahama S, et al. Prevalence of Corynebacterium ulcerans in dogs in Osaka, Japan. J Med Microbiol. 2012;61:266–273. Available from: https://doi.org/10.1099/jmm.0.034868-0

Diphtérie. Available from: https://www.santepubliquefrance.fr/maladies-et-traumatismes/maladies-a-prevention-vaccinale/diphterie

Zakikhany K, Efstratiou A. Diphtheria in Europe: current problems and new challenges. Future Microbiol. 2012;7:595–607. Available from: https://doi.org/10.2217/fmb.12.24

Konrad R, Hörmansdorfer S, Sing A. Possible human-to-human transmission of toxigenic Corynebacterium ulcerans. Clin Microbiol Infect. 2015;21:768–771. Available from: https://doi.org/10.1016/j.cmi.2015.05.021

Tiwari TS, Golaz A, Yu DT, Ehresmann KR, Jones TF, Hill HE, et al. Investigations of 2 cases of diphtheria-like illness due to toxigenic Corynebacterium ulcerans. Clin Infect Dis. 2008;46:395–401. Available from: https://doi.org/10.1086/525262

Otshudiema JO, Acosta AM, Cassiday PK, Hadler SC, Hariri S, Tiwari TSP. Respiratory illness caused by Corynebacterium diphtheriae and C. ulcerans, and use of diphtheria anti-toxin in the United States, 1996-2018. Clin Infect Dis. 2020;ciaa1218. Available from: https://doi.org/10.1093/cid/ciaa1218

Yamamoto A, Hifumi T, Ato M, Iwaki M, Senoh M, Hatanaka A, et al. Clinical characteristics of Corynebacterium ulcerans infection, Japan. Emerg Infect Dis. 2023;29:1505–1515. Available from: https://doi.org/10.3201/eid2908.220058

La maladie - Recommandations CNR Corynebactérie. Institut Pasteur. 2016. Available from: https://www.pasteur.fr/fr/sante-publique/CNR/les-cnr/corynebacteries-du-complexe-diphteriae/la-maladie-recommandations

Trégoat J-J. Health protection, diseases, drug addiction, epidemiology, vaccination, hygiene. Rev Francoph Lab. 2006;53–54.