Relieving Bowel Obstruction with EUS and Stenting

Main Article Content

Luke Taylor*
E Britton
S Granger
H Roach
S Norton
S Falk
M Finch-Jones
A Strickland
J Skipworth

Abstract

Abstract


A 61-year-old female with post-Whipple obstruction was treated successfully with EUS-guided stenting, resulting in rapid symptom relief and discharge. Using Endoscopic Ultrasound (EUS), a trans-gastric Self-Expanding Metal Stent (SEMS) was placed between the stomach and pancreatico-biliary roux limb, facilitating immediate drainage and symptom resolution.


MBO affects up to 15% of patients with cancer recurrence following Whipple's procedure. Meta-analyses assessing the outcomes of resectional/bypass palliative surgery for MBO demonstrate that re-obstruction rates are high (almost 50%) and morbidity and mortality are common (up to 90% and 40%, respectively).
However, more recent studies have demonstrated 90-100% success rates for EUS and stenting for relief of malignant biliary obstruction via choledochoduodenostomy and hepaticogastrostomy. Specialist centres have also described placement of gastroenterostomy stents to relieve malignant gastric outflow obstruction.


We propose considering EUS and stenting within the treatment algorithm of MBO patients with suitable anatomy.

Downloads

Download data is not yet available.

Article Details

Luke Taylor*, E Britton, S Granger, H Roach, S Norton, S Falk, M Finch-Jones, A Strickland, & J Skipworth. (2025). Relieving Bowel Obstruction with EUS and Stenting. Global Journal of Medical and Clinical Case Reports, 105–109. https://doi.org/10.17352/2455-5282.000209
Case Reports

Copyright (c) 2025 Taylor L, et al.

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Licensing and protecting the author rights is the central aim and core of the publishing business. Peertechz dedicates itself in making it easier for people to share and build upon the work of others while maintaining consistency with the rules of copyright. Peertechz licensing terms are formulated to facilitate reuse of the manuscripts published in journals to take maximum advantage of Open Access publication and for the purpose of disseminating knowledge.

We support 'libre' open access, which defines Open Access in true terms as free of charge online access along with usage rights. The usage rights are granted through the use of specific Creative Commons license.

Peertechz accomplice with- [CC BY 4.0]

Explanation

'CC' stands for Creative Commons license. 'BY' symbolizes that users have provided attribution to the creator that the published manuscripts can be used or shared. This license allows for redistribution, commercial and non-commercial, as long as it is passed along unchanged and in whole, with credit to the author.

Please take in notification that Creative Commons user licenses are non-revocable. We recommend authors to check if their funding body requires a specific license.

With this license, the authors are allowed that after publishing with Peertechz, they can share their research by posting a free draft copy of their article to any repository or website.
'CC BY' license observance:

License Name

Permission to read and download

Permission to display in a repository

Permission to translate

Commercial uses of manuscript

CC BY 4.0

Yes

Yes

Yes

Yes

The authors please note that Creative Commons license is focused on making creative works available for discovery and reuse. Creative Commons licenses provide an alternative to standard copyrights, allowing authors to specify ways that their works can be used without having to grant permission for each individual request. Others who want to reserve all of their rights under copyright law should not use CC licenses.

Meijer LL, Alberga AJ, de Bakker JK, van der Vliet HJ, Le Large TYS, van Grieken NCT, et al. Outcomes and treatment options for duodenal adenocarcinoma: a systematic review and meta-analysis. Ann Surg Oncol. 2018;25(9):2681–92. Available from: https://doi.org/10.1245/s10434-018-6567-6

Neoptolemos JP, Palmer DH, Ghaneh P, Psarelli EE, Valle JW, Halloran CM, et al. Comparison of adjuvant gemcitabine and capecitabine with gemcitabine monotherapy in patients with resected pancreatic cancer (ESPAC-4): a multicentre, open-label, randomised, phase 3 trial. Lancet. 2017;389(10073):1011–24. Available from: https://doi.org/10.1016/S0140-6736(16)32409-6

Groot VP, Rezaee N, Wu W, Cameron JL, Fishman EK, Hruban RH, et al. Patterns, timing, and predictors of recurrence following pancreatectomy for pancreatic ductal adenocarcinoma. Ann Surg. 2018;267(5):936–45. Available from: https://doi.org/10.1097/sla.0000000000002234

Neoptolemos JP, Stocken DD, Friess H, Bassi C, Dunn JA, Hickey H, et al. A randomized trial of chemoradiotherapy and chemotherapy after resection of pancreatic cancer. N Engl J Med. 2004;350(12):1200–10. Available from: https://doi.org/10.1056/nejmoa032295

Jones RP, Psarelli EE, Jackson R, Ghaneh P, Halloran CM, Palmer DH, et al. Patterns of recurrence after resection of pancreatic ductal adenocarcinoma. JAMA Surg. 2019;154(10):1038. Available from: https://doi.org/10.1001/jamasurg.2019.3337

Groot VP, Gemenetzis G, Blair AB, Ding D, Javed AA, Burkhart RA, et al. Implications of the pattern of disease recurrence on survival following pancreatectomy for pancreatic ductal adenocarcinoma. Ann Surg Oncol. 2018;25(8):2475–83. Available from: https://doi.org/10.1245/s10434-018-6558-7

Iacobuzio-Donahue CA, Fu B, Yachida S, Luo M, Abe H, Henderson CM, et al. DPC4 gene status of the primary carcinoma correlates with patterns of failure in patients with pancreatic cancer. J Clin Oncol. 2009;27(12):1806–13. Available from: https://doi.org/10.1200/jco.2008.17.7188

Strobel O, Hartwig W, Hackert T, Hinz U, Berens V, Grenacher L, et al. Re-resection for isolated local recurrence of pancreatic cancer is feasible, safe, and associated with encouraging survival. Ann Surg Oncol. 2013;20(3):964–72. Available from: https://doi.org/10.1245/s10434-012-2762-z

Wild AT, Hiniker SM, Chang DT, Tran PT, Khashab MA, Limaye MR, et al. Re-irradiation with stereotactic body radiation therapy as a novel treatment option for isolated local recurrence of pancreatic cancer after multimodality therapy: experience from two institutions. J Gastrointest Oncol. 2013;4(3):343–51. Available from: https://doi.org/10.3978/j.issn.2078-6891.2013.044

Hammel P, Huguet F, van Laethem JL, Goldstein D, Glimelius B, Artru P, et al. Effect of chemoradiotherapy vs chemotherapy on survival in patients with locally advanced pancreatic cancer controlled after 4 months of gemcitabine with or without erlotinib. JAMA. 2016;315(17):1844. Available from: https://doi.org/10.1001/jama.2016.4324

Reddy AV, Hill CS, Sehgal S, He J, Zheng L, Herman JM, et al. Stereotactic body radiation therapy for the treatment of locally recurrent pancreatic cancer after surgical resection. J Gastrointest Oncol. 2022;13(3):1402–12. Available from: https://doi.org/10.21037/jgo-22-38

Groot VP, van Santvoort HC, Rombouts SJ, Hagendoorn J, Borel Rinkes IH, van Vulpen M, et al. Systematic review on the treatment of isolated local recurrence of pancreatic cancer after surgery; re-resection, chemoradiotherapy and SBRT. HPB (Oxford). 2017;19(2):83–92. Available from: https://doi.org/10.1016/j.hpb.2016.11.001

Labori KJ, Hjermstad MJ, Wester T, Buanes T, Loge JH. Symptom profiles and palliative care in advanced pancreatic cancer—a prospective study. Support Care Cancer. 2006;14(11):1126–33. Available from: https://doi.org/10.1007/s00520-006-0067-0

Colina A, Raghav KPS, Katz MHG, Das P, Ikoma N, Koay EJ, et al. Pattern of recurrence after curative resection of stage I–III duodenal adenocarcinoma. J Clin Oncol. 2020;38(4_suppl):794. Available from: https://doi.org/10.1200/JCO.2020.38.4_suppl.794

Blair SL, Chu DZ, Schwarz RE. Outcome of palliative operations for malignant bowel obstruction in patients with peritoneal carcinomatosis from nongynecological cancer. Ann Surg Oncol. 2001;8(8):632–7. Available from: https://doi.org/10.1007/s10434-001-0632-1

Tran E, Spiceland C, Sandhu NP, Jatoi A. Malignant bowel obstruction in patients with recurrent ovarian cancer. Am J Hosp Palliat Care. 2016;33(3):272–5. Available from: https://doi.org/10.1177/1049909114566225

Laval G, Marcelin-Benazech B, Guirimand F, Chauvenet L, Copel L, Durand A, et al. Recommendations for bowel obstruction with peritoneal carcinomatosis. J Pain Symptom Manage. 2014;48(1):75–91. Available from: https://doi.org/10.1016/j.jpainsymman.2013.08.022

Franke AJ, Iqbal A, Starr JS, Nair RM, George TJ. Management of malignant bowel obstruction associated with GI cancers. J Oncol Pract. 2017;13(7):426–34. Available from: https://doi.org/10.1200/jop.2017.022210

Olson TJ, Pinkerton C, Brasel KJ, Schwarze ML. Palliative surgery for malignant bowel obstruction from carcinomatosis: a systematic review. JAMA Surg. 2014;149(4):383–92. Available from: https://doi.org/10.1001/jamasurg.2013.4059

Tuca A, Guell E, Martinez-Losada E, Codorniu N. Malignant bowel obstruction in advanced cancer patients: epidemiology, management, and factors influencing spontaneous resolution. Cancer Manag Res. 2012;4:159–69. Available from: https://doi.org/10.2147/cmar.s29297

Caparica R, Amorim L, Amaral P, Uratani L, Muniz D, Hendlisz A, et al. Malignant bowel obstruction: effectiveness and safety of systemic chemotherapy. BMJ Support Palliat Care. 2020;bmjspcare-2020-002656. Available from: https://doi.org/10.1136/bmjspcare-2020-002656

Patterson M, Greenley S, Ma Y, Bullock A, Curry J, Smithson J, et al. Inoperable malignant bowel obstruction: palliative interventions outcomes – mixed-methods systematic review. BMJ Support Palliat Care. 2022;13:e515–e527. Available from: https://doi.org/10.1136/bmjspcare-2021-003492

Leung Ki EL, Napoleon B. EUS-specific stents: available designs and probable lacunae. Endosc Ultrasound. 2019;8(Suppl 1):S17–S27. Available from: https://doi.org/10.4103/eus.eus_50_19

Fugazza A, Colombo M, Anderloni A. Biliopancreatic endoscopy: new solutions to old issues. GE Port J Gastroenterol. 2022;29(2):77–79. Available from: https://doi.org/10.1159/000521630

Park SW, Lee SS. Which are the most suitable stents for interventional endoscopic ultrasound? J Clin Med. 2020;9(11):3595. Available from: https://doi.org/10.3390/jcm9113595

de Benito Sanz M, Nájera-Muñoz R, de la Serna-Higuera C, Fuentes-Valenzuela E, Fanjul I, Chavarría C, et al. Lumen apposing metal stents versus tubular self-expandable metal stents for endoscopic ultrasound-guided choledochoduodenostomy in malignant biliary obstruction. Surg Endosc. 2021;35(12):6754–62. Available from: https://doi.org/10.1007/s00464-020-08179-y

Anderloni A, Fugazza A, Troncone E, Auriemma F, Carrara S, Semeraro R, et al. Single-stage EUS-guided choledochoduodenostomy using a lumen-apposing metal stent for malignant distal biliary obstruction. Gastrointest Endosc. 2019;89(1):69–76. Available from: https://doi.org/10.1016/j.gie.2018.08.047

Winkler J, Caillol F, Ratone JP, Bories E, Pesenti C, Giovannini M. Feasibility of EUS-guided hepaticogastrostomy for inoperable malignant hilar biliary strictures. Endosc Ultrasound. 2021;10(1):51–56. Available from: https://doi.org/10.4103/eus.eus_68_20

Nakai Y, Sato T, Hakuta R, Ito Y, Isayama H, Koike K, et al. Long-term outcomes of a long, partially covered metal stent for EUS-guided hepaticogastrostomy in patients with malignant biliary obstruction (with video). Gastrointest Endosc. 2020;92(3):623–631.e1. Available from: https://doi.org/10.1016/j.gie.2020.03.3856

Khashab MA, Kumbhari V, Grimm IS, Ngamruengphong S, Aguila G, El Zein M, et al. EUS-guided gastroenterostomy: the first U.S. clinical experience (with video). Gastrointest Endosc. 2015;82(5):932–8. Available from: https://doi.org/10.1016/j.gie.2015.06.017

Khashab MA, Bukhari M, Baron TH, Nieto J, El Zein M, Chen YI, et al. International multicenter comparative trial of endoscopic ultrasonography-guided gastroenterostomy versus surgical gastrojejunostomy for the treatment of malignant gastric outlet obstruction. Endosc Int Open. 2017;5(4):E275–E281. Available from: https://doi.org/10.1055/s-0043-101695

Kerdsirichairat T, Irani S, Yang J, Brewer Gutierrez OI, Moran R, Sanaei O, et al. Durability and long-term outcomes of direct EUS-guided gastroenterostomy using lumen-apposing metal stents for gastric outlet obstruction. Endosc Int Open. 2019;7(2):E144–E150. Available from: https://doi.org/10.1055/a-0799-9939

Khashab MA. EUS-guided gastroenterostomy vs duodenal stenting for the palliation of malignant gastric outlet obstruction. Gastroenterol Hepatol (N Y). 2019;15(5):323–325. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6676360/

DeWitt JM, Arain M, Chang KJ, Sharaiha R, Komanduri S, Muthusamy VR, et al. Interventional endoscopic ultrasound: current status and future directions. Clin Gastroenterol Hepatol. 2021;19(1):24–40. Available from: https://doi.org/10.1016/j.cgh.2020.09.029

Westerveld D, Hajifathalian K, Carr-Locke D, Sampath K, Sharaiha R, Mahadev S. Endoscopic ultrasound-guided ileosigmoidostomy using a lumen-apposing metal stent for palliation of malignant small-bowel obstruction. VideoGIE. 2022;7(1):109–111. Available from: https://doi.org/10.1016/j.vgie.2021.12.007

Sooklal S, Kumar A. EUS-guided enterocolostomy for palliation of malignant distal small-bowel obstruction. VideoGIE. 2019;4(11):530–531. Available from: https://doi.org/10.1016/j.vgie.2019.07.015

James TW, Nakshabendi R, Baron TH. EUS-guided ileocolonic anastomosis for relief of complete small-bowel obstruction. VideoGIE. 2020;5(8):428–430. Available from: https://doi.org/10.1016/j.vgie.2020.05.004