Antimicrobial Photodynamic Therapy (Helbo®) as an Adjunctive Approach for the Preservation of Dental Implants Following Early Postoperative Surgical Wound Dehiscence: A Case Report
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Abstract
Background: Early postoperative surgical wound dehiscence following dental implant placement is an uncommon but clinically significant complication that may result in alveolar bone exposure, bacterial contamination, impaired soft tissue healing, and possible implant failure. Although various treatment strategies have been described, there is currently no standardised management protocol, and clinical evidence regarding the adjunctive use of antimicrobial photodynamic therapy (aPDT) in this setting remains limited. This case highlights the potential clinical value of antimicrobial photodynamic therapy (HELBO®) as part of a multidisciplinary treatment approach for preserving newly placed dental implants. This case report aimed to present the successful preservation of newly placed dental implants affected by early postoperative surgical wound dehiscence using adjunctive HELBO® antimicrobial photodynamic therapy.
Case Presentation: This case report describes a 74-year-old completely edentulous male patient with severe mandibular alveolar ridge atrophy who underwent placement of two implants in the interforaminal region to improve the retention of a mandibular complete overdenture. Several days after surgery, early postoperative surgical wound dehiscence developed, resulting in loss of primary wound closure and exposure of the alveolar bone. Initial surgical wound revision and atraumatic resuturing failed to achieve stable wound closure. A comprehensive treatment protocol consisting of mechanical debridement, systemic antibiotic therapy, and adjunctive antimicrobial photodynamic therapy (HELBO®) was subsequently implemented to control bacterial contamination, promote soft tissue healing, and preserve the implants.
Results: The treatment resulted in progressive resolution of inflammation, formation of healthy granulation tissue, complete secondary wound epithelialization, and successful preservation of both implants. Clinical and radiographic follow-up confirmed stable osseointegration, enabling successful completion of the planned implant-retained mandibular overdenture rehabilitation. Adjunctive antimicrobial photodynamic therapy combined with meticulous local wound care resulted in complete secondary wound healing without signs of infection or implant failure. The implants remained clinically stable and were successfully preserved throughout follow-up.
Conclusion: This case demonstrates the successful management of early postoperative surgical wound dehiscence with alveolar bone exposure through a comprehensive treatment protocol incorporating adjunctive antimicrobial photodynamic therapy (HELBO®). The successful preservation of both implants, achievement of complete secondary wound healing, and uneventful osseointegration highlight the potential clinical value of this minimally invasive adjunctive therapy in managing biologic complications following implant surgery. Further prospective clinical studies are warranted to establish its effectiveness and define its role in evidence-based treatment protocols.
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Jung RE, Zembic A, Pjetursson BE, Zwahlen M, Thoma DS. Systematic review of the survival rate and the incidence of biological, technical, and aesthetic complications of single crowns on implants reported in longitudinal studies with a mean follow-up of 5 years. Clin Oral Implants Res. 2012;23(Suppl 6):2-21. Available from: https://academy.iti.org/iti-academy-consensus/CC5_Group2_2.pdf
Berglundh T, Armitage G, Araujo MG, Avila-Ortiz G, Blanco J, Camargo PM, et al. Peri-implant diseases and conditions: Consensus report of workgroup 4 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions. J Clin Periodontol. 2018;45(Suppl 20):S286-S291. Available from: https://doi.org/10.1111/jcpe.12957
Buser D, Sennerby L, De Bruyn H. Modern implant dentistry based on osseointegration: 50 years of progress, current trends and open questions. Periodontol 2000. 2017;73(1):7-21. Available from: https://doi.org/10.1111/prd.12185
Sanz M, Chapple IL, on behalf of Working Group 4 of the VIII European Workshop on Periodontology. Clinical research on peri-implant diseases: consensus report of Working Group 4. J Clin Periodontol. 2012;39(Suppl 12):202-206. Available from: https://doi.org/10.1111/j.1600-051x.2011.01837.x
Aghaloo TL, Misch C, Lin GH, Iacono VJ, Wang HL. Bone augmentation of the edentulous maxilla for implant placement: a systematic review. Int J Oral Maxillofac Implants. 2016;31(Suppl):s19-s30. Available from: https://doi.org/10.11607/jomi.16suppl.g1
Tavelli L, Barootchi S, Avila-Ortiz G, Urban IA, Giannobile WV, Wang HL. Peri-implant soft tissue phenotype modification and its impact on peri-implant health: A systematic review and network meta-analysis. J Periodontol. 2021 Jan;92(1):21-44. Available from: https://doi.org/10.1002/jper.19-0716
Lindhe J, Lang NP, Karring T, editors. Clinical Periodontology and Implant Dentistry. 6th ed. Wiley. 2015. Available from: https://content.e-bookshelf.de/media/reading/L-3498021-5d03b95cd1.pdf
Buser D, Martin W, Belser UC. Optimising esthetics for implant restorations in the anterior maxilla: anatomic and surgical considerations. Int J Oral Maxillofac Implants. 2004;19(Suppl):43-61. Available from: https://pubmed.ncbi.nlm.nih.gov/15635945/
Sanz M, Chapple ILC. Clinical research on peri-implant diseases: Consensus report of Working Group 4. J Clin Periodontol. 2012;39(Suppl 12):202-206. Available from: https://doi.org/10.1111/j.1600-051x.2011.01837.x
Sculean A, Gruber R, Bosshardt DD. Soft tissue wound healing around teeth and dental implants. J Clin Periodontol. 2014;41(Suppl 15):S6-S22. Available from: https://doi.org/10.1111/jcpe.12206
Buser D, Sennerby L, De Bruyn H. Modern implant dentistry based on osseointegration: 50 years of progress, current trends and open questions. Periodontol 2000. 2017;73(1):7-21. Available from: https://onlinelibrary.wiley.com/doi/abs/10.1111/prd.12185
Esposito M, Grusovin MG, Chew YS, Coulthard P, Worthington HV. Interventions for replacing missing teeth: 1- versus 2-stage implant placement. Cochrane Database Syst Rev. 2018;5(5): CD006698. Available from: https://doi.org/10.1002/14651858.cd006698.pub2
Herrera D, Berglundh T, Schwarz F, Chapple I, Jepsen S, Sculean A, et al. EFP workshop participants and methodological consultant. Prevention and treatment of peri-implant diseases-The EFP S3 level clinical practice guideline. J Clin Periodontol. 2023 Jun;50 Suppl 26:4-76. Available from: https://doi.org/10.1111/jcpe.13823
Heitz-Mayfield LJ, Mombelli A. The therapy of peri-implantitis: a systematic review. Int J Oral Maxillofac Implants. 2014;29 Suppl:325-45. Available from: https://doi.org/10.11607/jomi.2014suppl.g5.3
Renvert S, Polyzois I. Treatment of pathologic peri-implant pockets. Periodontol 2000. 2018;76(1):180-190. Available from: https://doi.org/10.1111/prd.12149
Al-Qahtani NA. Assessment of the position and level of mental nerve for placement of implants using cone-beam computed tomography & panoramic radiograph in the Saudi population. Saudi Dent J. 2022;34(4):315-320. Available from: https://doi.org/10.1016/j.sdentj.2022.04.001
Juarez C, Langa L, Mendoza R, Guerrero ME, Oliva J, Mayta-Tovalino F. Antimicrobial Photodynamic Therapy for the Treatment of Peri-implantitis: A Literature Review. J Int Soc Prev Community Dent. 2022;13(2):83-88. Available from: https://pubmed.ncbi.nlm.nih.gov/37223446/
Satpathy A, Grover V, Kumar A, Jain A, Gopalakrishnan D, Grover HS, et al. Indian Society of Periodontology Good Clinical Practice Recommendations for Peri-implant Care. J Indian Soc Periodontol. 2024;28(1):6-31. Available from: https://doi.org/10.4103/jisp.jisp_124_24
Hamblin MR, Hasan T. Photodynamic therapy: a new antimicrobial approach to infectious disease? Photochem Photobiol Sci. 2004;3:436-450. Available from: https://pubmed.ncbi.nlm.nih.gov/15122361/
Wilson M. Lethal photosensitisation of oral bacteria and its potential application in the photodynamic therapy of oral infections. J Antimicrob Chemother. 2004;53:899-906. Available from: https://doi.org/10.1039/b211266c
Maisch T. Resistance in antimicrobial photodynamic inactivation of bacteria. Photochem Photobiol Sci. 2015;14:1518-1526. Available from: https://doi.org/10.1039/c5pp00037h
Qin YL, Luan XL, Bi LJ, Sheng YQ, Zhou CN, Zhang ZG. Comparison of toluidine blue-mediated photodynamic therapy and conventional scaling treatment for periodontitis in rats. J Periodontal Res. 2008;43(2):162-7. Available from: https://doi.org/10.1111/j.1600-0765.2007.01007.x
Al Habashneh R, Asa’ad FA, Khader Y. Photodynamic therapy in periodontal and peri-implant diseases. Quintessence Int. 2015 Sep;46(8):677-90. Available from: https://doi.org/10.3290/j.qi.a34078
Bassir SH, Moslemi N, Jamali R, Mashmouly S, Fekrazad R, Chiniforush N, et al. Photoactivated disinfection using light-emitting diode as an adjunct in the management of chronic periodontitis: a pilot double-blind split-mouth randomised clinical trial. J Clin Periodontol. 2013;40(1):65-72. Available from: http://onlinelibrary.wiley.com/doi/10.1111/jcpe.12024
Christodoulides N, Nikolidakis D, Chondros P, Becker J, Schwarz F, Rössler R, et al. Photodynamic therapy as an adjunct to non-surgical periodontal treatment: a randomised, controlled clinical trial. J Periodontol. 2008;79(9):1638-44. Available from: https://doi.org/10.1902/jop.2008.070652
Sgolastra F, Petrucci A, Severino M, Graziani F, Gatto R, Monaco A. Adjunctive photodynamic therapy to non-surgical treatment of chronic periodontitis: a systematic review and meta-analysis. J Clin Periodontol. 2013;40(5):514-26. Available from: https://pubmed.ncbi.nlm.nih.gov/23557433
Dougherty TJ, Gomer CJ, Henderson BW, Jori G, Kessel D, Korbelik M, et al. Photodynamic therapy. J Natl Cancer Inst. 1998;90(12):889-905. Available from: https://doi.org/10.1093/jnci/90.12.889
Aebisher D, Czech S, Dynarowicz K, Misiołek M, Komosińska-Vassev K, Kawczyk-Krupka A, et al. Photodynamic Therapy: Past, Current, and Future. Int J Mol Sci. 2024;25(20):11325. Available from: https://doi.org/10.3390/ijms252011325
Alvarez N, Sevilla A. Current Advances in Photodynamic Therapy (PDT) and the Future Potential of PDT-Combinatorial Cancer Therapies. Int J Mol Sci. 2024;25(2):1023. Available from: https://doi.org/10.3390/ijms25021023
Aebisher D, Szpara J, Bartusik-Aebisher D. Advances in Medicine: Photodynamic Therapy. Int J Mol Sci. 2024;25(15):8258. Available from: https://doi.org/10.3390/ijms25158258
Yan Y, Rotundo R, Suvan J, Orlandi M, Poma A, D’Aiuto F. Photodynamic therapy and peri-implant diseases: a systematic review and meta-analysis. Front Oral Health. 2025 9;6:1614982. Available from: https://doi.org/10.3389/froh.2025.1614982
Wang HL, Boyapati L. “PASS” principles for predictable bone regeneration. Implant Dent. 2006;15(1):8-17. Available from: https://doi.org/10.1097/01.id.0000204762.39826.0f
Berglundh T, Armitage G, Araujo MG, Avila-Ortiz G, Blanco J, Camargo PM, et al. Peri-implant diseases and conditions: Consensus report of workgroup 4 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions. J Clin Periodontol. 2018;45 Suppl 20:S286-S291. Available from: https://doi.org/10.1111/jcpe.12957
Schwarz F, Derks J, Monje A, Wang HL. Peri-implantitis. J Clin Periodontol. 2018;45 Suppl 20:S246-S266. Available from: https://doi.org/10.1111/jcpe.12954
Lang NP, Berglundh T, Working Group 4 of Seventh European Workshop on Periodontology. Periimplant diseases: where are we now?--Consensus of the Seventh European Workshop on Periodontology. J Clin Periodontol. 2011;38:178-81. Available from: https://doi.org/10.1111/j.1600-051x.2010.01674.x
Albrektsson T, Brånemark PI, Hansson HA, Lindström J. Osseointegrated titanium implants. Requirements for ensuring a long-lasting, direct bone-to-implant anchorage in man. Acta Orthop Scand. 1981;52(2):155-70. Available from: https://doi.org/10.3109/17453678108991776
Abrahamsson I, Berglundh T, Linder E, Lang NP, Lindhe J. Early bone formation adjacent to rough and turned endosseous implant surfaces. An experimental study in the dog. Clin Oral Implants Res. 2004;15(4):381-92. Available from: https://doi.org/10.1111/j.1600-0501.2004.01082.x
Derks J, Tomasi C. Peri-implant health and disease. A systematic review of current epidemiology. J Clin Periodontol. 2015;42:S158-71. Available from: https://doi.org/10.1111/jcpe.12334
Chrcanovic BR, Kisch J, Albrektsson T, Wennerberg A. Factors Influencing Early Dental Implant Failures. J Dent Res. 2016;95(9):995-1002. Available from: https://doi.org/10.1177/0022034516646098
Khoury F, Hanser T. Three-Dimensional Vertical Alveolar Ridge Augmentation in the Posterior Maxilla: A 10-year Clinical Study. Int J Oral Maxillofac Implants. 2019;34(2):471-480. Available from: https://doi.org/10.11607/jomi.6869
Lindhe J, Berglundh T. The interface between the mucosa and the implant. Periodontol 2000. 1998;17:47-54. Available from: https://doi.org/10.1111/j.1600-0757.1998.tb00122.x
Urban IA, Nagursky H, Lozada JL, Nagy K. Horizontal ridge augmentation with a collagen membrane and a combination of particulated autogenous bone and inorganic bovine bone-derived mineral: a prospective case series in 25 patients. Int J Periodontics Restorative Dent. 2013;33(3):299-307. Available from: https://doi.org/10.11607/prd.1407
Zucchelli G, Mazzotti C, Mounssif I, Mele M, Stefanini M, Montebugnoli L. A novel surgical-prosthetic approach for soft tissue dehiscence coverage around a single implant. Clin Oral Implants Res. 2013;24(9):957-62. Available from: https://doi.org/10.1111/clr.12003
Romanos GE, Delgado-Ruiz R, Sculean A. Concepts for prevention of complications in implant therapy. Periodontol 2000. 2019;81(1):7-17. Available from: https://doi.org/10.1111/prd.12278
Lin GH, Chan HL, Wang HL. The significance of keratinised mucosa on implant health: a systematic review. J Periodontol. 2013;84(12):1755-67. Available from: https://doi.org/10.1902/jop.2013.120688
Chambrone L, Wang HL, Romanos GE. Antimicrobial photodynamic therapy for the treatment of periodontitis and peri-implantitis: An American Academy of Periodontology best evidence review. J Periodontol. 2018;89(7):783-803. Available from: https://doi.org/10.1902/jop.2017.170172
Nastri L, Annunziata M, Mariani P, Guida A, Di Mare MGP, Guida L. The Effect of Adjunctive Antimicrobial Photodynamic Therapy in the Treatment of Peri-Implant Diseases: Systematic Review and Meta-Analysis. Dent J. 2025;13(12):567. Available from: https://doi.org/10.3390/dj13120567
Shahbazi S, Esmaeili S, Moscowchi A, Amid R, Romanos G, Kadkhodazadeh M. Adjunctive photochemical therapy for management of inflammatory peri-implant diseases: A systematic review and meta-analysis. Photochem Photobiol. 2026;102:163-197. Available from: https://onlinelibrary.wiley.com/doi/10.1111/php.14098?af=R
Jervøe-Storm PM, Bunke J, Worthington HV, Needleman I, Cosgarea R, MacDonald L, et al. Adjunctive antimicrobial photodynamic therapy for treating periodontal and peri-implant diseases. Cochrane Database Syst Rev. 2024;7(7):CD011778. Available from: https://doi.org/10.1002/14651858.cd011778.pub2
Tardelli JDC, Melo-Soares V, Carvalho-Silva JM, Uehara LM, Ferreira I, Reis AC. Antimicrobial photodynamic therapy in the treatment of peri-implantitis: From evolution to clinical efficacy – A systematic review with meta-analysis. J Drug Deliv Sci Technol. 2026;124:108551. Available from: http://sciencedirect.com/science/article/pii/S1773224726005769?__cf_chl_rt_tk=hCXBE8BpWeB8DsICzH.inpfcDF2VMKs2geBE4PdDTyo-1785326025-1.0.1.1-_KcPDqDdidSgOFt69R27yG4AcdcngjkSVuhQYDfGvj0
Hamblin MR. Antimicrobial photodynamic inactivation: a bright new technique to kill resistant microbes. Curr Opin Microbiol. 2016;33:67-73. Available from: https://doi.org/10.1016/j.mib.2016.06.008
Garcia de Carvalho G, Sanchez-Puetate JC, Casalle N, Marcantonio Junior E, Leal Zandim-Barcelos D. Antimicrobial photodynamic therapy associated with bone regeneration for peri-implantitis treatment: A case report. Photodiagnosis Photodyn Ther. 2020;30:101705. Available from: https://doi.org/10.1016/j.pdpdt.2020.101705