Accidental Acute Poisoning of two Children by Paracetamol-Codeine (1000 Mg/60 Mg) Association - A Case Report

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Global Journal of Medical and Clinical Case Reports volume3-issue1 articles
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Submitted: January 28, 2016
Published: Mar 1, 2016
DOI: 10.17352/2455-5282.000023

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A Diallo*
Department of Toxicology, Faculty of Health Sciences, University of Lome, Togo
M Eliassou
Department of Toxicology, Faculty of Health Sciences, University of Lome, Togo
K Djadou
Department of Pediatrics, Faculty of Health Sciences, Université de Lomé, Togo
Y Potchoo
Department of Pharmacololy, Faculty of Health Sciences, University of Lome, Togo
EE Creppy
Department of Toxicology, Faculty of Health Sciences, University of Lome, Togo

Abstract

Paracetamol is one of the most used drugs in the world. We report here two cases of children poisoning (less than 3 years old) who were accidentally administered an adult form of rectal suppository containing a combination of paracetamol-codeine (1000 mg/60 mg). The first child received a dose of 154 mg /kg of paracetamol and 9 mg/kg of codeine two times daily for 2 days. Clinical signs were vomiting and epigastric abdominal pains. Biochemistry showed an increase of liver enzymes (4 to 40 fold), alanine aminotransferase (ALT), aspartate aminotransferase (AST) and gamma glutamyl transpeptidase (GGT). The second child received the suppositories discontinuously (two times daily) and showed less severe signs of intoxication. The administration of N-acetylcysteine at admission into hospital limited the toxic effects of paracetamol. The toxic effects of codeine, such as central nervous system (CNS) depression were not obvious in both cases.

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Article Details

Diallo, A., Eliassou, M., Djadou, K., Potchoo, Y., & Creppy, E. (2016). Accidental Acute Poisoning of two Children by Paracetamol-Codeine (1000 Mg/60 Mg) Association - A Case Report. Global Journal of Medical and Clinical Case Reports, 3(1), 005–007. https://doi.org/10.17352/2455-5282.000023
Case Reports

Copyright (c) 2016 Diallo A, et al.

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This work is licensed under a Creative Commons Attribution 4.0 International License.

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