An unusual presentation revealing pancreatic carcinoma: Sister Mary Joseph Nodule
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Abstract
Sister Mary Joseph Nodule (SMJN) is a cutaneous nodule resulting from metastasis of malignant tumors affecting the umbilicus; it had been reported in 0.7e10.4% of patients.
This case report describes an 82-year-old male diagnosed with metastatic pancreatic adenocarcinoma and confirmed by the biopsy of Sister Mary Joseph’s nodule.
The aim of this presentation is too aware of such a specific manifestation, enables the physicians to investigate the underlying malignancy and to show the role of biopsy of the nodule for the diagnosis of the primitive cancer.
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Copyright (c) 2019 Sghir H, et al.

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Tso S, Brockley J, Recica H, Ilchyshyn A (2013) Sister Mary Joseph’s nodule: an unusual but important physical finding characteristic of widespread internal malignancy. Br J Gen Pract 63: 551-552. Link: http://bit.ly/33i7pAc
Omura T, Tamura Y, Kodera R, Oba K, Toyoshima K, et al. (2019) Pancreatic cancer manifesting as Sister Mary Joseph nodule during follow up of a patient with type 2 diabetes mellitus: A case report. Geriatr Gerontol Int 19: 363-364. Link: http://bit.ly/2pHelIq
Amaro R, Goldstein JA, Cely CM, Rogers AI (1999) Pseudo Sister Mary Joseph’s nodule. Am J Gastroenterol 94: 1949-1950. Link: http://bit.ly/2pHeAmO
Calista D, Fiorentini C, Landi G (2002) Umbilical metastasis from ovarian carcinoma: Sister Mary Joseph’s Nodule. J Eur Acad Dermatol Venereol 16: 84-85. Link: http://bit.ly/2qivbNR
Panaro F, Andorno E, Di Domenico S, Morelli N, Bottino G, et al. (2005) Sister Joseph's nodule in a liver transplant recipient: case report and mini-review of literature. World J Surg Oncol 3: 4-10. Link: http://bit.ly/2NcYLxd
Chiang CH, Lin MH (2015) Sister Mary Joseph nodule associated with pancreatic adenocarcinoma. J Formos Med Assoc 114: 92-93. Link: http://bit.ly/2qivPuL
Nally C, Preshaw RM (1994) Tumour implantation at umbilicus after laparoscopic cholecystectomy for unsuspected gallbladder carcinoma. Can J Surg J Can Chir 37: 243-244. Link: http://bit.ly/2qkyHqS
Limmathurotsakul D, Rerknimitr P, Korkij W, Noppakun N, Kullavanijaya P, et al. (2007) Metastatic mucinous cystic adenocarcinoma of the pancreas presenting as Sister Mary Joseph's nodule. JOP 8: 344-349. Link: http://bit.ly/36pOO7n
Crescentini F, Deutsch F, Sobrado CW, Araújo Sd (2004) Umbilical mass as the sole presenting sign of pancreatic cancer: a case report. Rev Hosp Clín Fac Med S Paulo 59: 198-202. Link: http://bit.ly/2NG1Gxk
Varadhachary GR, Abbruzzese JL, Lenzi R (2004) Diagnostic strategies for unknown primary cancer. Cancer 100: 1776-1785. Link: http://bit.ly/2rctXUX
Jun DW, Lee OY, Park CK, Choi HS, Yoon BC, et al. (2005) Cutaneous metastases of pancreatic carcinoma as a first clinical manifestation. Korean J Intern Med 20: 260-263. Link: http://bit.ly/2raFS5D
Shwartz RA (1998) Metastatic cancer of the skin. Skin Cancer Recognition and Management. New York: Springer-Verlag 185-193.
Clements AB (1952) Metastatic carcinoma of the umbilicus. JAMA 150: 556-559. Link: http://bit.ly/2NC27c5
Chatterjee SN, Bauer HM (1980) Umbilical metastasis from carcinoma of the pancreas. Arch Dermatol 116: 954-955. Link: http://bit.ly/33eyXXc
Charoenkul V, DelCampo A, Derby A, Hodgson WJ, McElhinney AJ (1977) Tumors of the umbilicus. Mt Sinai J Med 44: 257-262. Link: http://bit.ly/2PLbpW6
Majmudar B, Wiskind AK, Croft BN, Dudley AG (1991) The Sister Mary Joseph nodule: its significance in gynecology. Gynecol Oncol 40: 152-159. Link: http://bit.ly/2WKSBaP
Gabriele R, Conte M, Egidi F, Borghese M (2005) Umbilical metastases: current viewpoint. World J Surg Oncol 3: 13. Link: http://bit.ly/2C7qOYE
Palaniappan M, Jose WM, Mehta A, Kumar K, Pavithran K (2010) Umbilical metastasis: a case series of our Sister Joseph nodules from four different visceral malignancies. Current Oncol 17: 78-81. Link: http://bit.ly/36ymaAM
Gabriele R, Conte M, Egidi F, Borghese M (2005) Umbilical metastasis: current viewpoint. World J Surg Oncol 3: 313-315. Link: http://bit.ly/36zK5QG