Anthracycline-based combination chemotherapy (Doxorubicin and Dacarbazine) for the desmoid tumor in a neoadjuvant setting. Report of a case

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Global Journal of Medical and Clinical Case Reports volume8-issue1 articles
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Submitted: April 7, 2021
Published: Apr 26, 2021
DOI: 10.17352/2455-5282.000124

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Mahmood S
Consultant Medical Oncologist, Canberra Hospital, Clinical Lecturer, ANU Medical School, Australia
Divyanshu Dua*
Consultant Medical Oncologist, Canberra Hospital, Clinical Lecturer, ANU Medical School, Australia

Abstract

We report a case of a 41-years-old female with a sporadic abdominal wall desmoid tumor. After a period of 12-months observation, chemotherapy was given with Doxorubicin and Dacarbazine to facilitate minimal surgery. The patient received 4 cycles of chemotherapy. Treatment was well tolerated and resulted in a significant reduction of the tumor size from 48mm to 25mm, 48% reduction. The tumor was surgically resected, and the histopathology from the resected specimen revealed a partial pathological response. At 6 months post-surgery, there is no recurrence or surgical complications.

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Article Details

S, M., & Dua, D. (2021). Anthracycline-based combination chemotherapy (Doxorubicin and Dacarbazine) for the desmoid tumor in a neoadjuvant setting. Report of a case. Global Journal of Medical and Clinical Case Reports, 8(1), 038–040. https://doi.org/10.17352/2455-5282.000124
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Copyright (c) 2021 Mahmood S, et al.

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Gounderx MM, Mahoney MR, Van Tine BA, Ravi V, Attia S, et al, (2018) Sorafenib for advanced and refractory Desmoid Tumors. NEJM 379:2417-2428. Link: https://bit.ly/3ew38jE

Toulmonde M, Pulido M, Ray-Coquard I, Andre T, Isambert N, et al, (2019) Pazopanib or methotrexate-vinblastine combination chemotherapy in adult patients with progressive desmoid tumours (DESMOPAZ): a non-comparative, randomised, open-label, multicentre, phase 2 study. Lancet Oncol 20:1263. Link: https://bit.ly/3xkvnu8

Patel SR, Evans HL, Benjamin RS (1993) Combination chemotherapy in adult desmoid tumors.Cancer 72:3244-3247. Link: https://bit.ly/3ep31pU

Gega M, Yanagi H, Yoshikawa R, Noda M, Ikeuchi H, et al, (2006) Successful chemotherapeutic modality of doxorubicin plus dacarbazine for the treatment of desmoid tumors in association with familial adenomatous polyposis. J Clin Oncol 24:102-105. Link: https://bit.ly/2QiG6ok

Azzarelli A, Gronchi A, Bertulli R, Tesoro JD, Baratti D, et al. (2001) Low-dose chemotherapy with methotrexate and vinblastine for patients with advanced aggressive fibromatosis. Cancer 92:1259-1264. Link: https://bit.ly/32H1iH6

Palassini E, Frezza AM, Mariani L, Lalli L, Colombo C, et al, (2017) Long-term Efficacy of Methotrexate Plus Vinblastine/Vinorelbine in a Large Series of Patients Affected by Desmoid-Type Fibromatosis. Cancer J 23:86-91. Link: https://bit.ly/3xcCMvv