Markov Models of Genomic Events

Main Article Content

Orchidea Maria Lecian Sapienza*

Abstract

The Markov Models of genomic elements are newly considered. The representation of the fundamental matrix of the Markov model is newly theorised. The order of magnitude of the initial conditions for the elements of the transition probabilities is newly hypothesised.


The model is compared with a sub-Hidden Markov Model of genomic events. The chosen representation of the states is newly proven to consist of an enveloping algebra. The new condition is posed on the Markovian feature of the originating chain from the study of the elements of the loci of the state space; in this case, the choice of the representation of the probability matrix is analytically spelled out, and Monte Carlo methods are not necessitated.

Downloads

Download data is not yet available.

Article Details

Lecian Sapienza, O. M. (2024). Markov Models of Genomic Events. Global Journal of Medical and Clinical Case Reports, 11(3), 018–020. https://doi.org/10.17352/2455-5282.000181
Short Communications

Copyright (c) 2024 Sapienza OML.

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Georg P, Grasedyck L, Klever M, Schill R, Spang R, Wettig T. Low-rank tensor methods for Markov chains with applications to tumor progression models. J Math Biol. 2022;86(1):7. Available from: https://doi.org/10.1007/s00285-022-01846-9.

Hjelm M, Hoeglund M, Lagergren J. New probabilistic network models and algorithms for oncogenesis. J Comput Biol. 2006:853-865. Available from: https://doi.org/10.1089/cmb.2006.13.853.

Beerenwinkel N, Sullivant S. Markov models for accumulating mutations. Biometrika. 2009;96:645-661. Available from: https://doi.org/10.1093/biomet/asp023.

Schill R, Solbrig S, Wettig T, Spang R. Modelling cancer progression using Mutual Hazard Networks. Bioinformatics. 2019;36:241-249. Available from: https://doi.org/10.1093/bioinformatics/btz513.

Gotovos A, Burkholz R, Quackenbush J, Jegelka S. Scaling up continuous-time Markov chains helps resolve underspecification. arXiv. 2021. arXiv:2107.02911. Available from: https://doi.org/10.48550/arXiv.2107.02911.

Ji H, Mascagni M, Li Y. Convergence analysis of Markov chain Monte Carlo linear solvers using Ulam-von Neumann Algorithm. SIAM J Numer Anal. 2013;51(4):2107-2122. Available from: https://doi.org/10.1137/130904867.

Fathi-Vajargah B, Hassanzadeh Z. Improvements on the hybrid Monte Carlo algorithms for matrix computations. Sa'dhana'. 2019;44(1):1. Available from: https://doi.org/10.1007/s12046-018-0983-y.

Beerenwinkel N, Schwarz RF, Gerstung M, Markowetz F. Cancer Evolution: Mathematical Models and Computational Inference. Syst Biol. 2015;64. Available from: https://doi.org/10.1093/sysbio/syu081.

Choo-Wosoba H, Albert PS, Zhu B. A hidden Markov modeling approach for identifying tumor subclones in next-generation sequencing studies. Biostatistics. 2022;23:69-82. Available from: https://doi.org/10.1093/biostatistics/kxaa013

Bailey MH, Tokheim C, Porta-Pardo EL, et al. Comprehensive characterization of cancer driver genes and mutations. Cell. 2018;173(2):371-385.e18. Available from: https://doi.org/10.1016/j.cell.2018.02.060.

Buchholz P, Dayar T. On the convergence of a class of multilevel methods for large sparse Markov chains. SIAM J Matrix Anal Appl. 2007;29(3):1025-1049. Available from: https://doi.org/10.1137/060651161.

Plateau B, Stewart WJ. Stochastic automata networks. In: International series in operations research and management science. New York: Springer; 2000. p. 113-151. Available from: https://link.springer.com/chapter/10.1007/978-1-4757-4828-4_5

Lecian OM. Analytical results from the two-states Markovv-states model and applications to validation of molecular dynamics. Int J Math Comput Res. 2023;11(9):3746-3754. Available from: https://doi.org/10.47191/ijmcr/v11i9.08

Lecian OM. Laplace Kernels with Radon measures in Galerkin Markov-State Models: new theorems about analytical expressions of time evolution of eigenvalues and about errors. e-print. 2024. Available from: http://dx.doi.org/10.13140/RG.2.2.24311.39841/1