Alkaline diet and long term preservation of renal function in stage 5 CKD
Main Article Content
Abstract
Kidneys produce bicarbonate ions that neutralize acids in the blood. Patients suffering from Chronic Kidney Disease (CKD) often present metabolic acidosis, as the kidney can no longer neutralize the acid load. Alkaline diet based on fruits, vegetables and mostly plant protein may have a positive effect on long-term preservation of the renal function in patients with stage 4-5 CKD while maintaining the nutritional status.
Downloads
Article Details
Copyright (c) 2020 Athanasiadou V, et al.

This work is licensed under a Creative Commons Attribution 4.0 International License.
Brown L, Luciano A, Pendergast J, Khairallah P, Anderson CAM, et al. (2019) Predictors of Net Acid Excretion in the Chronic Renal Insufficiency Cohort (CRIC) Study. Am J Kidney Dis 74: 203-212. Link: https://bit.ly/2Tx3wEN
Passey C (2017) Reducing the Dietary Acid Load: How a More Alkaline Diet Benefits Patients with Chronic Kidney Disease. J Ren Nutr 27:151-160. Link: https://bit.ly/2A3aYAl
Siener R (2018) Dietary Treatment of Metabolic Acidosis in Chronic Kidney Disease. Nutrients 10: E512. Link: https://bit.ly/3bVWLTk
Hu MK, Witham MD, Soiza RL (2019) Oral Bicarbonate Therapy in Non-Haemodialysis Dependent Chronic Kidney Disease Patients: A Systematic Review and Meta-Analysis of Randomised Controlled Trials. J Clin Med 8: 208. Link: https://bit.ly/2TrXPHW
de Brito-Ashurst I, Varagunam M, Raftery MJ, Yaqoob MM (2009) Bicarbonate supplementation slows progression of CKD and improves nutritional status. J Am Soc Nephrol 20: 2075–2084. Link: https://bit.ly/2WT9rWN
Shah S, Abramowitz M, Hostetter T, Melamed M (2009) Serum bicarbonate levels and the progression of kidney disease: a cohort study. Am J Kidney Dis 54: 270-277. Link: https://bit.ly/36tVGB6
Scialla JJ, Anderson CAM (2013) Dietary acid load: A novel nutritional target in chronic kidney disease? Adv Chronic Kidney Dis 20: 141–149. Link: https://bit.ly/3em1kIj
Wesson DE (2006) Regulation of kidney acid excretion by endothelins. Kidney International 70: 2066-2073. Link: https://bit.ly/2LRWEgM
Kelly JT, Palmer SC, Wai SN, Ruospo M, Carrero JJ, et al. (2017) Healthy Dietary Patterns and Risk of Mortality and ESRD in CKD: A Meta-Analysis of Cohort Studies. Clin. J Am Soc Nephrol 12: 272–279. Link: https://bit.ly/2WRIbIb
Goraya N, Simoni J, Jo CH, Wesson DE (2014) Treatment of metabolic acidosis in patients with stage 3 chronic kidney disease with fruits and vegetables or oral bicarbonate reduces urine angiotensinogen and preserves glomerular filtration rate. Kidney Int 86: 1031-1038. Link: https://bit.ly/3ggBqan
Kieffer DA, Piccolo BD, Vaziri ND, Liu S, Lau WL, et al. (2016) Resistant starch alters gut microbiome and metabolic profiles concurrent with amelioration of chronic kidney disease in rats. Am J Physiol 310: F857–F871. Link: https://bit.ly/2XjON10
Laffin MR, Tayebi Khosroshahi H, Park H, Laffin LJ, Madsen K, et al. (2019) Amylose resistant starch (HAM-RS2) supplementation increases the proportion of Faecalibacterium bacteria in end-stage renal disease patients: Microbial analysis from a randomized placebo-controlled trial. Hemodial Int 23: 343-347. Link: https://bit.ly/3gfjrRG